Journal of Biochemistry & Molecular Biology
Volume 2, No. 1, 2024
Pages 60-75
DOI: 10.36108/jbmb/4202.20.0160
Hypoglycaemic and Hypolipidaemic effect of Aristolochia bracteolata Lam (Doman Duste) Rhizomes Extract on Alloxan Induced Diabetic Rats
* MUHAMMED Amina Asabe1, DAVID Jane2, BELLO Zainab3, OGUNMEFUN Gbenga Samson4, and YUSUF Hajara Oyiza5
1 Biotechnology Department, Nigerian Defence Academy, Kaduna
2 Medical Biotechnology Department, National Biotechnology Research and Development Agency, Umaru Musa Yar’adua Expressway, Lugbe, Abuja – Nigeria
3 Environmental Biotech and Bioconservation Department, National Biotechnology Research and Development Agency, Umaru Musa Yar’adua Expressway, Lugbe, Abuja – Nigeria
4 Technology and Innovation Support Centre under the DG/CEO, National Biotechnology Research and Development Agency, Umaru Musa Yar’adua Expressway, Lugbe, Abuja – Nigeria
5Bio entrepreneurship and Consultancy Services Department, National Biotechnology Research and Development Agency, Umaru Musa Yar’adua Expressway, Lugbe, Abuja – Nigeria
*Corresponding Author- Email:muhammadaminah30@gmail.com Orcid No: https://orcid.org/0009-0000-7223-498X
Abstract
This study examines the hypoglycemic and hypolipidemic effects of rhizome extract from Aristolochia bracteolata Lam (Doman Duste) on rats with alloxan-induced diabetes. Aqueous extracts of the rhizome were given to groups of rats with and without diabetes, and blood glucose and lipid profiles were then measured. The results showed that both the diabetes untreated and treated groups saw a mean decrease in body weight from 143.33 ± 5.77 to 136.67 ± 4.73 g and 167.67 ± 1.53 to 159.67 ± 0.58 g, respectively, following the induction of the alloxan. After the diabetic rats were treated, their body weight climbed from 159.67 ± 0.58 to 169.67 ± 0.58 g, and all of them regained their previous body weight. Following alloxan induction, the diabetic untreated rat group’s serum glucose levels were higher (7.91 ± 0.07 mmol) than those of the normal untreated (6.13 ± 0.49 mmol/L), normal treated (6.70 ± 0.50 mmol/L), and diabetic treated (6.30 ± 0.17 mmol/L) groups. The diabetic untreated rats had lower HDL-cholesterol (2.51 ± 0.45 mmol/L) than the other groups, but greater triacylglyceride (3.19 ± 0.79 mmol/L), VLDL-cholesterol (1.77 ± 0.56 mmol/L), and LDL-cholesterol (1.44 ± 0.36 mmol/L). Out of the four groups, the diabetic untreated rat group’s atherogenic index (AI) seems to be the highest (1.27 ± 1.75). This study emphasizes A. bracteolata potential as a natural treatment for lipid regulation and diabetic management.
Keywords: Alloxan-induced diabetes, Aristolochia bracteolata, Diabetes mellitus, Herbal medicine, Hypoglycaemic, Hypolipidaemic.
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